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HFpEF is characterized by the presence of different comorbidities such as type-2 diabetes mellitus (T2DM), visceral obesity and ageing, all contributing to systemic metabolic inflammation [7, 8]
Sensitivity analyses To verify the robustness of the data, we performed three sensitivity analyses: First, in order to account for potential unmeasured confounding by including an active comparator, we evaluated the risk of incident NAION in persons treated with sodium-glucose transport protein 2 (SGLT2) inhibitors (ATC: A10BK01 [ n = 84,283], A10BK02 [ n = 3048], A10BK03 [ n = 85,892], A10BK04 [ n = 96]) versus once-weekly semaglutide with or without redemption of prescriptions for SGLT2 inhibitors
Badole SL, Bagul PP, Mahamuni SP, Khose RD, Joshi AC, Jangam GB, Ghule AE, Raut CG, Khedkar VM, Coutinho EC
Conclusion GLP-1 RAs provide clinically meaningful weight loss primarily through selective fat mass reduction, with relative preservation of lean tissue, supporting their role in achieving quality weight loss
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