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During the transition window, some patients experience temporary hunger return or mild side effects as their system adjusts to the new medication

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In addition to directly influencing satiety and appetite control via hypothalamic and hindbrain pathways, GLP-1RAs appear to engage higher-order networks involved in reward processing and emotional regulation, such as the insula, amygdala, and medial prefrontal cortex

Those on metformin and sitagliptin (100 mg/day) directly entered the double-blind treatment period

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations