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After 10 min, 0.8 mL of 0.5M 4- mercaptophenylacetic acid (MPAA) solution is added to the peptide hydrazide solution to cause in-situ thiolysis of the peptidyl azide generated from Preparation 39

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An important barrier to uptake is the high cost of these medications [10]

This study represents the longest real-world investigation of oral semaglutide to date