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Calories measure energy quantity but do not determine how the body regulates appetite or fat storage
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In healthy physiology, there is a dynamic equilibrium between desensitization and resensitization that maintains overall receptor responsiveness despite continuous agonist presence
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Notably, Compound 86 engaged only F392 and F424 and formed a single hydrogen bond with H267, whereas 8HP and DSR-141562 displayed additional interactions with H373, Q421, D370, and Y222, with 8HP exhibiting the highest affinity due to extra aromatic contacts (Figures 26AC)
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