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Yet healthcare providers still prescribe it in specific medical cases with proper oversight

Given the copper pathways implicated, users with pre-existing copper overload, Wilson disease, or severe liver disease may be at increased risk and should avoid use

Jul 1999;14(7):1690-7

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Although many of the actions of sulphonylureas and glinides are therefore attributable to the actions of endogenous insulin, additional actions may also be mediated by direct effects on skeletal muscle K ATP channels