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It is important to note that whilst these mechanisms are biologically plausible, the presence of a theoretical mechanism does not automatically translate to clinical efficacy

Always consult a qualified physician before starting any weight-loss medication or program

Other weight loss medications may work with a dual mechanism, mimicking two natural hormones and helping to manage appetite in addition to increasing insulin sensitivity

If FDA were to place these drugs on the DDC list, the drugs would not qualify for certain statutory exemptions under the Federal Food, Drug and Cosmetic Act, and most importantly, the drugs will not be allowed to be compounded by pharmacists, physicians or outsourcing facilities under any circumstances, even in a shortage, Beaver said

For example, in human experiments conducted by Tang et al., TMAO plasma levels were markedly decreased after administration of antibiotics but returned to the previous level after withdrawal of antibiotics (59)

However, a denial isnt always the final word