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Although anti-IGF-IR mAbs and IGF-IR inhibitors have potent anti-cancer effects in preclinical models, clinical trials of these agents are largely disappointing in unselected cancer patients

We also thank Barbara Bassani, Daniela Farioli, Annalisa Bosi, Francesca Caudano and Matilde Tramacere for preliminary experiments

CAN BE ADDED TO GLP TO INCREASE SYNERGISTIC EFFECT Cagrilintide is a next-generation metabolic peptide designed to regulate appetite, support weight loss, and enhance glucose metabolism

These mechanisms contribute to its broad regenerative effects observed in animal models across musculoskeletal, gastrointestinal, and systemic systems

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