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In IELs specifically, the activation of GLP-1R signaling suppresses phosphorylation of chainassociated protein kinase 70 (ZAP70) and its downstream target SH2 domaincontaining leukocyte protein 76 (SLP-76), leading to dampening of proximal T cell receptor signaling and reduced cytokine transcription

M., & Kwakowsky, A

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Reference: Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society Mozaffarian, Dariush et al

[3] [4] Administered as a once-weekly subcutaneous injection, Wegovy works by mimicking the action of the naturally occurring hormone GLP-1