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Block Adrenaline: They prevent adrenaline (epinephrine) and noradrenaline (norepinephrine) from binding to beta-adrenergic receptors in the body

In clinical trials, treatment with tirzepatide produced superior weight loss and glycemic control compared to GLP-1RAs 3,17 , suggesting that agonism at both the GIPR and GLP-1R is beneficial in humans with type 2 diabetes

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References Grau-Bov C, Gonzlez-Quilen C, Cantini G, Nardini P, Espina B, Bani D, Terra X, Blay M, Rodrguez-Gallego E, Luconi M, Ardvol A, Pinent M

Methods 17 , 4144 (2020)