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Bioavailability is the degree and rate at which a substance is absorbed into the bloodstream and becomes available at the intended site of action
Given the redundant nature of immunosuppressive pathways in the TME, co-targeting the TIGIT/CD155 axis alongside PD-1 blockadepotentially facilitated by multi-payload nanomedicine delivery systemsrepresents a highly promising frontier for overcoming resistance and restoring robust antitumor immunity
PMID: 15591013
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