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A trial published in The New England Journal of Medicine (2023) demonstrated mean weight reductions of up to approximately 24% of body weight over 48 weeks in adults with obesity a potentially significant finding if confirmed in Phase 3 trials

Heart disease and stroke statistics-2020 update: a report from the American Heart Association

Below are evidence-based protocols for each compound, as well as a transition protocol for researchers moving between them

1,2 The primary composite outcome occurred in 6.5% of patients treated with Wegovy and 8.0% with placebo

As of September 2, 2025,, a group lawsuit representing people hurt by Wegovy has added 486 new plaintiffs

At the same time, U.S