Preclinical studies have demonstrated that liraglutide significantly suppresses obesity-associated breast cancer cell proliferation via modulation of adipokine expression, with enhanced antineoplastic effects observed in obese populations [122]
Safety is ensured by careful patient screening, starting with low doses, increasing gradually, regular monitoring, and medical supervision throughout
This may involve mtDNA biomarker-guided ART selection, where screening for pre-existing mtDNA haplogroups or mutational burdens identifies individuals at higher risk for specific ART toxicities, enabling proactive selection of less harmful regimen (e.g., avoiding certain NRTIs in susceptible individuals)
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Tales efectos son coherentes con un incremento de la oxidacin lipdica evidenciado por la disminucin del cociente respiratorio y con una modulacin de los circuitos hipotalmicos que regulan la recompensa alimentaria