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Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, et al
J Biol Chem 276:3943839447
However, novel dual receptor agonists have been developed for the treatment of obesity and T2D under the concept that GLP-1 restrains the hyperglycemic action of glucagon, while allowing it to exert its beneficial actions on bodyweight, food intake, lipid metabolism and thermogenesis (71)
However, the therapeutic landscape is nuanced
The impact on postprandial glucose-lowering of altering the timing of metformin administration in relation to meals has been poorly characterised, although an open-label pilot study in five metformin-treated type 2 diabetes patients was indicative of improved glucose-lowering, enhanced GLP-1 secretion and slowed gastric emptying when metformin (1000 mg) was administered 30 min before the meal rather than with the meal [24]
A significantly decreases GSH levels in MC65 nerve cells, increases nonenzymatic and enzymatic oxidation of arachidonic acid (COX, 5-LOX, 12-LOX, and 15-LOX), and increases mitochondrial ROS levels and total intracellular lipid peroxides
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