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The American Journal of Clinical Nutrition , 69 (6), 11351143
In this blog post, well summarize the latest research on GLP-1 receptor agonists, their mechanisms, and their potential applications in mental health
Why brain-based GLP-1 activity matters clinically: It helps explain the appetite-suppressing effects of GLP-1 receptor agonist medications It may contribute to neuroprotective mechanisms being investigated in neurodegenerative diseases It potentially influences cognitive processes and mood regulation, though human evidence remains limited It provides insight into the gut-brain axis and metabolic-neurological interactions Understanding GLP-1's cerebral actions has become particularly relevant as GLP-1 receptor agonistsoriginally developed for type 2 diabetesare now also licensed for weight management in the UK (NICE TA875, TA664)
[14] [15] Borderline results warrant further assessment rather than reassurance alone
L-GSH supplementation in individuals with T2DM for 3-months also resulted in improved control of in vitro BCG infection when compared to the placebo group ( Figure 6A )
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