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Interrelationship Between Baseline HbA1c, SGLT-2 Inhibitor Use and Risk of Diabetic Ketoacidosis in Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis

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#TreatmentResistantDepression #Ketamine #Esketamine #Neuroplasticity #MentalHealth #EvidenceBasedMedicine #PrecisionMedicine #BrainanBody To view or add a comment, sign in : Most antidepressants improve mood. But many patients still say: "I feel better but I still can't think straight." That's where vortioxetine stands apart. It isn't just another antidepressant. Its multimodal pharmacology gives it a unique role in patients struggling with the cognitive symptoms of depression. Cognitive improvements have been demonstrated in clinical studies. Benefits may occur even when mood improvement is only partial. That suggests cognition is being addressed through more than simply improving depressive symptoms. Inhibits the serotonin transporter (SERT) 5-HT1A agonist 5-HT3 antagonist 5-HT7 antagonist This receptor profile is thought to support executive function, attention, and processing speed beyond serotonin reuptake inhibition alone. Although 5 mg is an approved starting dose, it is often insufficient for meaningful clinical response. Most patients who benefit require 1020 mg daily. Avoid judging effectiveness before an adequate therapeutic trial. Nausea is the most common adverse effect. Taking it with food and slower titration can improve tolerability. Patients should know nausea often improves after 23 weeks, reducing unnecessary discontinuation. ' - Generic vortioxetine is now available in many markets. Review insurance formularies before ruling it out. For patients with depression plus significant cognitive dysfunction, prior authorization may be worthwhile. When a patient says, "My mood is better, but my brain still isn't working." Think beyond symptom scores. Vortioxetine isn't the right choice for every patient. But for depression accompanied by persistent cognitive dysfunction, its unique receptor profile makes it an option worth considering. . . ' . For educational purposes only

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Wang MT, Bolland MJ, Grey A