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nanoparticles can catalyze Fenton reactions and also increase lipid peroxidation [204]

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Both cholesterol saturation index and the hydrophobic index of the bile acid pool will increase in bile, paving the way to supersaturation of gallbladder bile, biliary sludge and gallstones [77,78,79]

Comparison conditions were as follows: month 0, accelerated 6 months and extended 12 months of testing

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However, the exact roles of oxidative stress and antioxidant in carcinogenesis have been controversial because oxidative stress can promote or suppress tumor development in different contexts 30