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Monitoring liver function during treatment is crucial, given that the study did not deploy invasive liver surveillance such as biopsies

Consider the following recommendations: Eat your final meal at least 34 hours before bedtime to allow adequate time for digestion Avoid large evening meals , opting instead for smaller, lighter dinners Stay upright for at least 2 hours after eating to facilitate gastric emptying and reduce discomfort Avoid trigger foods that may exacerbate nausea or reflux, particularly in the evening Maintain adequate hydration throughout the day, but reduce fluid intake close to bedtime Sleep hygiene practices remain fundamental for managing sleep disturbances: Maintain a consistent sleep schedule , going to bed and waking at similar times daily Create a relaxing bedtime routine to signal your body that sleep is approaching Ensure your bedroom is cool, dark, and quiet Limit screen time for at least one hour before bed Avoid caffeine after early afternoon and limit alcohol consumption Managing gastrointestinal side effects can significantly improve sleep quality

Nicola Magrini, Unit head for Innovation, Evidence synthesis and Clinical research, University Hospital, Bologna, Italy, Co-Chair of the Guidelines Development Group Comments: GLP-1 and inclusion in the essential medicine Mr Deus Mubangizi, Director, Medicines and Health Products Policies and Standards Department, WHO Panel discussion Ms Jeanette Hunter General Primary Health Care at the National Department of Health (NDoH) of South Africa, and Co-Chair of the Guidelines Development Group

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