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There has been some controversy regarding the glucagonostatic effect of GLP-1RAs, and whether such an effect exists

Quick answer: Semaglutide diarrhoea is a common but usually temporary side effect caused by changes in digestion, slowed gastric emptying, and GLP-1 hormone activation

Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Stambolija V, Zoricic Z, Vrcic H, Sebecic B

The latest move builds on the agency's decision in September to add semaglutide and tirzepatide, active ingredients in Novo Nordisk's Ozempic and Eli Lilly's Mounjaro, to its essential medicines list for managing type 2 diabetes in high-risk groups

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Clinical trial data shows discontinuation rates of 4-7% due to GI side effects for semaglutide, and slightly higher (6-9%) for tirzepatide, likely because higher doses are used