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Notably, researchers have documented that the peptide appears to upregulate NO production when it is deficient and downregulate it when excessive, suggesting a modulatory rather than simply stimulatory relationship
This is not specific to B12 but reflects the sensitivity of the gastrointestinal tract in these conditions
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Hamdan One Health Mycology 1: 37-46 (2024)
Chronic kidney disease patients often demonstrate elevated B12 levels, particularly those on dialysis
Storage conditions that shorten unopened shelf life: heat (extended exposure above 25C), freezing and re-thawing (can crack the stopper seal), direct sunlight (degrades benzyl alcohol), and humid environments (can degrade label readability and obscure exp date)
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