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This side effect often occurs in conjunction with other gastrointestinal disturbances, such as nausea and vomiting

- Appetite Regulation: Targets hormones that control hunger, helping patients feel satisfied with smaller meals

CD8 + T cells of the knockout mice were intrinsically defective in balancing homeostasis in the peripheral environment, implicating GPX4 is required for T cell-regulated immune responses (Matsushita et al., 2015)

The NHS does not set an upper safe limit for B12 because harmful effects from excessive intake have not been definitively established

The NHS provides specialist endocrine input for dose optimisation and patient education regarding sick-day rules and emergency management

The quality of available evidence is further limited by methodological concerns, including small sample sizes, short study durations, lack of standardisation in probiotic formulations, and potential publication bias favouring positive results