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Additionally, BCL2-inhibitors have been shown to have senolytic effects in some senescent cell models 1,4

Overexpressed IGFBP-1 in transgenic mice shows that its increase produces hyperinsulinaemia accompanied by glucose intolerance, and that this process is dependent upon IGFBP-1 phosphorylation statewhich is increased in diabetes [259]

Depression and health-related quality of life in maintenance hemodialysis patients

In ApoE -/- mice on a high-fat diet (HFD), TMAO supplementation significantly increased vascular plaque progression, macrophage recruitment, and CD36/pro-inflammatory cytokine expression

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