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Nonetheless, the exact mechanisms underlying the GLP-1 RA-associated HR acceleration are still unclear and these preliminary study results involving healthy male subjects cannot be over-generalized to a diabetic population using GLP-1 RAs

This concern likely stems from how frequently gastrointestinal side effects occur

It provides actionable evidence that if the goal is durable neural remodeling and mTOR suppression, continuous intranasal administration is vastly superior to sporadic systemic injections

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Developmental Cell , 57 (14), 1712

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