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Hepatic stellate cells (HSCs) were then exposed to conditioned media obtained from M0, M1, or M2 macrophages, both with and without TGF-

In one such trial the 68-week STEP 1 study adults receiving once-weekly subcutaneous semaglutide 2.4 mg demonstrated a mean body weight reduction of 14.9%, compared with 2.4% in the placebo group [1]

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In Drosophila melanogaster , the drug causes DNA double-strand breaks and cellular toxicity, which are mitigated by antioxidant treatment (e.g., ascorbic acid), indicating oxidative DNA damage (Jajoo et al., 2020)