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The weight loss itself reduces aromatase activity in fat tissue, allowing more Testosterone to remain unconverted to estrogen
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Diarrhea is a well-documented and relatively common adverse effect of semaglutide therapy
p21, cyclin-dependent kinase inhibitor 1A (also known as p21 WAF1/Cip1 )
Several factors contribute to this efficacy difference
doi: 10.1038/s41591-025-03774-9 182 GruberTLechnerFKriegerJPGarca-CceresC
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