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It describes the phenomenon where an oral glucose load provokes a much greater insulin response than an equivalent intravenous glucose infusion

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However, unlike GIP, GLP-1 has not been found to have a direct role in fat deposition in adipose tissues [16]

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However, in people with type 2 diabetes, GIP does not contribute at all to the total insulin secretion effect of the combination while the insulinotropic effect of GLP-1 is only slightly impaired

Uses : Semaglutide could be used to lower blood glucose in adults with type 2 diabetes and for promoting weight loss along with diet and increased physical activity