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MOTS-c is typically administered via subcutaneous injection into the abdomen, lateral thigh, or flank, rotating injection sites to prevent tissue accumulation

By including pyridoxine directly in the injection, the anti-nausea agent arrives in the body at exactly the same time as the peptide

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(a) The measurement of glycolysis in astrocytes isolated from WT mice and APP23 AD mice

Without specific proof as to the exact cause of why a GLP-1 could cause a higher risk of developing NAION, we can hypothesize a bit and suggest hypovolemia and dehydration from perhaps weight loss, especially if the patient is getting a medication for hypertension and the weight loss has reduced the need for the hypertensive agent and thus the patient develops hypotension