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PMID: 24310374 www.ncbi.nlm.nih.gov/pubmed/24310374
Yes, under medical supervision
Mechanistically, GLP-1 signaling suppresses M1-associated genes while enhancing that of M2-related genes through activation of signal transducer and activator of transcription 3 (STAT3) (Wan and Sun, 2019)
However, the long-term cardiovascular and renal benefits need to be carefully evaluated against the risk of DKA
It works by mimicking the action of ghrelin and binding to the growth hormone secretagogue receptor (GHSR) in the brain, which triggers the pituitary gland to release GH
If you accidentally take too much : GLP-1 receptor agonist overdose can cause severe nausea, vomiting, and potentially hypoglycemia, particularly in patients taking concurrent insulin or sulfonylureas (GLP-1 medications alone rarely cause hypoglycemia)
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