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Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma
Hsieh and colleagues (J Mol Med, 2017) reported that BPC 157 upregulated VEGFR2 expression and promoted receptor internalisation and downstream signalling in human umbilical vein endothelial cells, with increased tube formation in vitro and greater vessel density in a rodent hindlimb ischaemia model
NPGPx (GPx7): a novel oxidative stress sensor/transmitter with multiple roles in redox homeostasis
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To determine if the V229A substitution affected receptor recruitment to clathrin-coated pits (CCPs) after agonist stimulation, TIRF images were acquired of both unstimulated and exendin-4-stimulated INS-1 832/3 SNAP/FLAG-hGLP-1R WT versus V229A cells (Figure 5C)
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