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Moreover, in addition to alleviating hyperglycemia and hyperlipidemia, sitagliptin also ameliorated inflammation and oxidative stress by down-regulating JAK/STAT signaling pathway in diabetic rats, conferring evidence for the therapy of diabetic cardiomyopathy [106]

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Combining GLP-1 with Lifestyle Changes: GLP-1 Medications Work Best When Combined With: Nutrition: High-protein meals (20-30g per meal) Plenty of vegetables and fiber Adequate hydration Avoiding trigger foods that worsen nausea Physical Activity: Regular walking (30 minutes daily) Strength training (2-3x weekly to preserve muscle) Movement that you enjoy and will sustain Gradually increasing as weight decreases Behavioral Changes: Mindful eating practices Stress management Adequate sleep (7-9 hours) Support system GLP-1 medications make these changes easier by reducing hunger and cravings, but the lifestyle changes enhance results and improve overall health

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