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Updated July 2026 GLP-1 medications produce weight loss unlike anything medicine has offered before and to understand why, and why that weight loss tends to reverse once the drug stops, it helps to know what these drugs actually do inside the body

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B12, iron, zinc, and vitamin D begin accumulating

Product-specific titration instructions come from the current prescribing information

If you're taking insulin or sulfonylureas (glipizide, glimepiride, glyburide, and similar), adding a GLP-1 medication increases your risk of hypoglycemia