It increases risk without making the treatment more appropriate
S (Study design): Randomised controlled trials (RCTs), non-randomised controlled trials (N-RCTs), cohort studies, and case-control studies
doi: 10.1016/j.diabres.2023.110803 212 ZengL.YangK.HeQ.ZhuX.LongZ.WuY.et al
Clinical trials to test for effects of GLP-1s on a range of novel outcomes including alcohol use disorder and Alzheimers disease are already underway
For example, mail-order pharmacy rules, step therapy requirements, or obscure formulary changes can derail an otherwise valid claim
Safe Effective Possibly even protective in acute disease As the global burden of diabetes continues to rise, insights like this help guide better, more confident prescribing