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Studies suggest that a significant proportion of long-term metformin users may develop biochemical B12 deficiency, though estimates vary widely depending on the population studied, the duration of use, and the B12 threshold applied

It is important to note that B12 injections are not licensed or indicated for weight loss purposes in the UK

However, complete symptom resolution, particularly for neurological complications, may take several weeks to months depending on the severity and duration of deficiency before treatment

If your injection hurts more than a surface sting, you may need to adjust your angle to 45 degrees or ensure you are pinching enough tissue

Six-to-12 months later, the patients were asked to recall if their pain had improved

Known side effects can include mild swelling and bruising