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"These drugs act not only in the gut and brain areas that control hunger but also on taste bud cells and brain regions that process taste and reward," explains endocrinologist Othmar Moser, of the University of Bayreuth in Germany, who led the published research

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661 In an in vitro BBB model using hCMEC/D3 cells, it was demonstrated that TMA exposure increased paracellular permeability, whereas TMAO exposure enhanced barrier integrity and trans-endothelial electrical resistance (TEER)