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David Kellner, a rheumatologist at UCLA Health
Similar patterns are observed with tirzepatide discontinuation
A SURMOUNT-1 post-hoc analysis of 2,542 women, published in Obesity in 2025, found perimenopausal women on tirzepatide lost 23% of body weight against 3% on placebo, almost identical to the premenopausal result
In the gut, it slows gastric emptying by up to 70%, extending the postprandial (after-meal) period during which satiety hormones like GLP-1 and peptide YY remain elevated
For practical purposes, semaglutide is considered essentially cleared from your system after five half-lives, which works out to about 35 days or five weeks
For more information on GLP-1 Support from Whole Health Rx, visit www.vitaminshoppe.com/lp/glp1-weightloss.
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