Imaeda says newer and higherdose medications that are not yet FDA-approved may be effective for nonresponders
Wegovy injections may suit people who: Wegovy tablets may suit people who: Further reading: How to take Wegovy tablets Wegovy tablets and injections can cause similar side effects because they contain the same active ingredient, semaglutide

Other groups who may benefit include: Patients following gastric surgery (gastrectomy, bariatric procedures) where intrinsic factor production or absorption sites are compromised Individuals with malabsorption disorders such as Crohn's disease, coeliac disease, or chronic pancreatitis Strict vegans and vegetarians with dietary insufficiency, though oral supplementation is usually tried first Elderly patients with atrophic gastritis or reduced gastric acid production Patients on long-term metformin or proton pump inhibitors, which can impair B12 absorption [6] [8] Individuals with nitrous oxide exposure (recreational or medical), which can cause functional B12 deficiency Diagnosis typically involves serum B12 measurement, with levels below approximately 148 pmol/L (though thresholds vary between laboratories) generally indicating deficiency
Diabetes Research and Clinical Practice, 183 , Article 109119
UK researchers can consult the Retatrutide Evidence Dossier at Nexyra Lab for a structured summary of published preclinical and investigational literature
But neither of these replaces hydration, fiber, and movement - those are the foundation