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A recommendation for early termination due to safety reasons will be considered by the independent DSMB if the Haybittle-Peto boundary (p=0.001, Z=3) at a given interim analysis is crossed

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Blots were developed using ECL kit (Thermofisher) or scanned using the OdysseyIR scanner (Li-CORBiosciences, NE)

Stimulant laxatives like cascara may cause diarrhea and electrolyte loss, and so are generally recommended for short-term use only

Current scientific literature emphasizes early-stage model observations, and interpretations remain exploratory