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PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration
suis infection, could thus lead to changes in these neurotransmitters, affecting gutbrain signaling
Kobori T, Onishi Y, Yoshida Y, Tahara T, Kikuchi T, Kubota T, et al
PLoS ONE 8 , e76938 (2013)
This two-step engagement is why truncating the N-terminus abolishes activation while leaving binding partly intact, and it is why the position-8 modification can block a protease without destroying agonism: the residue is inside the activating segment but is tolerant of substitution
IUBMB Life 71 (4), 516-522
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