In experimental models for the induction of tissue damage, 20 mg/kg MTX was a commonly used dose for rats (Reference Moodi, Hosseini and Abedini16Reference Azadnasab, Kalantar and Khorsandi20)
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Notably, NU-0129, composed of siRNA targeting the GBM oncogene Bcl2Like12 (Bcl2L12) and a gold nanoparticle core, was the first spherical nucleic acid (SNA) drug administered systemically
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Furthermore, administering DBZ at a dose of 10 mg/kg over two consecutive days has been found to enhance L-cell numbers and GLP-1 secretion in rats fed a high-fat diet
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