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demonstrated that the Nrf2 agonists 4-octyl-itaconate and clinically approved dimethyl fumarate can inhibit the replication of several types of virus, including SARS-CoV-2 68 and ZIKV by an IFN-independent pathway 67

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10.1177/039463201202500123 Int J Immunopathol Pharmacol

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The chronic immune activation and mycotoxin burden of systemic Candida overgrowth places sustained demand on the hypothalamic-pituitary-adrenal (HPA) axis, progressively depleting cortisol reserve and producing the flat diurnal cortisol curve characteristic of adrenal fatigue