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Metformin Because extended-release metformin, compared with the immediate-release presentation, is associated with a lower incidence of gastrointestinal adverse effects, such as nausea, vomiting, dyspepsia, and diarrhea, opting for the extended-release presentation is the first step in preventing the adverse effects related to this medication.9,10 The mechanism of action through which metformin triggers gastrointestinal adverse effects is not known, but there is increasing evidence supporting the idea that the pathophysiologic mechanism is secondary to dysbiosis, given the reports that Intestinibacter spp
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Incretin-based therapy in the management of metabolic dysfunction-associated steatotic liver disease (MASLD): one piece of the puzzle: Editorial on Comparison of glucagon-like peptide-1 receptor agonists and thiazolidinediones on treating nonalcoholic fatty liver disease: a network meta-analysis
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Mason RP, Libby P, Bhatt DL