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Within controlled laboratory settings, 5-Amino-1MQ is utilized to study how NNMT inhibition alters intracellular nicotinamide handling and affects downstream metabolic signaling pathways, including those related to NAD+ homeostasis, mitochondrial dynamics, and adipocyte functionality
Male, 18-week-old C57BL/6J mice, maintained on a 60% high-fat diet (HFD
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