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Consequently, researchers should treat observed effects from the blend as exploratory findings reflecting the combined action of four mechanistically distinct compounds rather than as validated outcomes of a characterized formulation

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If anti-KLOW antibodies develop, they could theoretically cross-react with endogenous Klotho protein, creating an autoimmune-like suppression of the body's own protective signaling

This provides high-fidelity information on diseases and treatments in the whole period in which GLP-1 RAs and DPP-4is have been marketed in Denmark, allowing an unbiased study population with very little missing data, and providing results which are highly generalizable to other similar populations