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Stimulants, including amphetamine, methamphetamine, cocaine, and ephedrine exceeding regulatory thresholds, are banned in competition due to their alertness-promoting and fatigue-masking properties

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The Kraus 2014 study reported that adipocyte-specific NNMT knockdown in mice increased adipocyte energy expenditure through a mechanism interpreted as elevated methyl-donor availability for polyamine biosynthesis and for histone methylation that modulates adipocyte gene-expression programs [2]

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