While a study in chronic insomnia patients has reported that short-term DSIP administration is unlikely to be of major therapeutic benefit, a 16-month study in mice found that long-term DSIP administration increased maximum life span and decreased the rate of tumor growth [22, 23]
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The researchers recommend additional prospective studies to clarify the biological mechanisms underlying this association
SAEs, including agranulocytosis and neutropenia (9.7%), were also more frequent in this trial, highlighting the need to consider patient characteristics, particularly concurrent dopaminergic therapy, when evaluating DFP in PD
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