Some experts suggest that the caloric deficit induced by reduced appetite could contribute to feelings of tiredness, as well as shifts in hormone levels
Wegovy does not directly affect thyroid hormones, but weight loss achieved during treatment may influence thyroid medicine requirements
In addition to these conventional sites of mitochondrial ROS generation, it has been recently reported that the branched-chain 2-oxoacid dehydrogenase (BCKDH) complex in mitochondria can produce superoxide and H 2 O 2 at higher rates than complex I from mitochondria (Quinlan et al., 2014)
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This chronic inflammation drives fatigue, joint pain, muscle aches, brain fog, and mood disturbances that go far beyond simple thyroid hormone deficiency