21 The certainty of evidence for key outcomes was assessed using GRADE (risk of bias, inconsistency, indirectness, imprecision, and publication bias)
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Specifically, the Ganoderma mushroom species remains the highest producer of bioactive compounds with extensive pharmacological activities
78 One cohort study of over 4,000 participants in the sixth Korean National Health and Nutrition Examination Survey (20142015) suggested a dose-related effect of smoking status (based on urinary cotinine levels) on thyroid function and autoimmunity