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Astrocytes detect and upregulate transmission at inhibitory synapses of somatostatin interneurons onto pyramidal cells
In the STEP 1 extension trial, participants regained two-thirds of their lost weight within 12 months of stopping semaglutide (Wilding et al., Diabetes Obes Metab 2022)
Some patients regain weight rapidly within the first few months after discontinuation, while others experience a more gradual increase
Quick Answer: Small air bubbles in GLP-1 injection pens are safe and pose virtually no health risk because subcutaneous injections deposit medication into tissue, not blood vessels, where air is harmlessly absorbed
"A new framework for the diagnosis, staging and management of obesity in adults"
Its use remains confined to clinical trial settings, and any guidance on its management is therefore derived from trial protocols and the broader evidence base for the GLP-1 receptor agonist drug class
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