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doi: 10.1111/bph.12608 110 LiuJGaoDDingQZhangBZhuWShiY

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Our results showed that MCD diet feeding increased the protein levels of NLRP3 and ASC, and the full length and cleaved forms of Caspase-1 and GSDMD in the liver, in contrast, these upregulation were decreased by H 2 therapy (Figure 5)

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In contrast, CB-839 showed no antitumor activity in PDAC mouse models due to the use of alternative metabolic pathways (e.g., fatty acid and lipid metabolism) by these cancer cells 45

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