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This happens because the underlying metabolic dysfunction that caused the weight gain was never addressed
This could for example reveal ways to preserve muscle mass during weight loss, and regenerate knee cartilage for osteoarthritis
"It's exciting to see these new results from the cardiometabolic post hoc analysis, which showed that while benefits were most pronounced in people who achieved greater than 15% weight loss, clear improvements in glycemic parameters and CV risk factors were observed in patients taking oral semaglutide 25 mg, regardless of how much weight was lost, based on the groups observed." Additional OASIS 4 data Indirect comparison between formulations Data presented from an indirect treatment comparison of the OASIS 4 (oral semaglutide) and STEP 1 (injectable semaglutide) phase 3 clinical trials in adults with obesity and overweight demonstrated that key outcomes like the share of people reaching 5%, 10%, 15%, 20% body weight reductions, positive changes in cardiometabolic markers, and quality of life scores were comparable for the oral and injectable formulations in these trials, respectively
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