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In addition, IGF-1 LR3 has been shown to stimulate the differentiation and proliferation of satellite cells, which are responsible for repairing damaged muscle tissue

Consequently, robust validation in clinically relevant orthotopic and metastatic osteosarcoma models, rather than simple subcutaneous models, is urgently required for these approaches (1012)

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Might SLC25A39 or ATF4 be a target

This is where it gets tricky